Kurzfassung

The amino acid arginine is essential for the function of human T-lymphocytes. Arginine depletion during inflammatory reactions, as well as in tumor disease, leads to clinically relevant immune suppression and inhibition of the anti-tumor immune response, respectively. Arginine transport proteins, present in human T-lymphocytes, are therefore potential new targets for the pharmacological manipulation of T-cell functions.
In collaboration with PD Dr. Markus Munder (Medical University Mainz, Med...The amino acid arginine is essential for the function of human T-lymphocytes. Arginine depletion during inflammatory reactions, as well as in tumor disease, leads to clinically relevant immune suppression and inhibition of the anti-tumor immune response, respectively. Arginine transport proteins, present in human T-lymphocytes, are therefore potential new targets for the pharmacological manipulation of T-cell functions.
In collaboration with PD Dr. Markus Munder (Medical University Mainz, Med
 III.: Hematology, Oncology and Pneumology), we will investigate the following central questions concerning arginine transport in this system:
(1) Which transport proteins mediate the uptake of the amino acid arginine in human T-lymphocytes at rest, and upon activation and cellular stress (arginine depletion)?
(2) What is the subcellular localization of these proteins and how are they regulated?
(3) What other transport proteins affect, directly or indirectly, the availability of arginine in human T-lymphocytes?
(4) Can the function of human T-lymphocytes be regulated by selective modulation of specific transport proteins for arginine?
 
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