Kurzfassung

Oligodendrocytes synthesise the CNS myelin sheath by enwrapping axonal segments with elongations of their plasma membrane. Spatial and temporal control of membrane traffic is a prerequisite for proper myelin formation. The major myelin proteolipid protein (PLP) accumulates in late endosomal storage compartments and multivesicular bodies (MVBs). Fusion of MVBs with the plasma membrane results in the release of the intraluminal vesicles into the extracellular space, specified as exosomes.
The...Oligodendrocytes synthesise the CNS myelin sheath by enwrapping axonal segments with elongations of their plasma membrane. Spatial and temporal control of membrane traffic is a prerequisite for proper myelin formation. The major myelin proteolipid protein (PLP) accumulates in late endosomal storage compartments and multivesicular bodies (MVBs). Fusion of MVBs with the plasma membrane results in the release of the intraluminal vesicles into the extracellular space, specified as exosomes.
The aim of this project is to define the composition of the exosomal proteome by mass spectrometric methods.» weiterlesen» einklappen