Kurzfassung

Human papillomaviruses (HPV) are small DNA tumour viruses that inflict a significant burden of disease on the population.  The clinical manifestations caused by HPV range from anogenital warts and laryngeal papillomas to cancers at anogenital sites, such as the cervical cancer. The development of strategies to prevent HPV infection requires a deeper understanding of the mechanism of HPV infectivity.
 
We showed earlier that HPV16 virions enter cells through a novel entry pathway via...Human papillomaviruses (HPV) are small DNA tumour viruses that inflict a significant burden of disease on the population.  The clinical manifestations caused by HPV range from anogenital warts and laryngeal papillomas to cancers at anogenital sites, such as the cervical cancer. The development of strategies to prevent HPV infection requires a deeper understanding of the mechanism of HPV infectivity.
 
We showed earlier that HPV16 virions enter cells through a novel entry pathway via tetraspanin-enriched microdomains (Spoden et al., 2008; Scheffer et al., 2013; Spoden et al., 2013). This project will contribute to the understanding of this pathway by building upon novel data that link the tetraspanin CD63 and its associated adaptor protein syntenin-1 to HPV infection.  Importantly, our data indicate that the syntenin-associated pathway is important for trafficking of virus particles of more than one HPV type.» weiterlesen» einklappen