Kurzfassung

There is an unmet medical need for novel and more effective strategies in wound therapy. One factor affecting wound healing is the lack of metabolic energy. The aim of this project is the development of novel, regenerative active biomaterials for wound treatment by functionalization of wound gels and artificial skin with a novel type of smart, amorphous microparticles formed by polyphosphate and zinc ions (Zn-polyP-MP). These particles will confer to the biomaterials used for wound treatment...There is an unmet medical need for novel and more effective strategies in wound therapy. One factor affecting wound healing is the lack of metabolic energy. The aim of this project is the development of novel, regenerative active biomaterials for wound treatment by functionalization of wound gels and artificial skin with a novel type of smart, amorphous microparticles formed by polyphosphate and zinc ions (Zn-polyP-MP). These particles will confer to the biomaterials used for wound treatment novel and advantageous properties, namely the delivery of metabolic energy needed for wound healing. In addition, they are morphogenetically active, stimulate microvascularization and have an antibacterial effect. The task is the investigation of the underlying mechanism, including coacervate formation of the stable Zn-polyP microparticles upon contact with protein or protein-containing body fluids (such as blood or wound fluid) and its enzymatic degradation, whereby the released energy is converted into ATP. In in vitro studies the biological effects of the prepared materials, wound gels and their components will be investigated. Before animal experiments, experiments with artificial skin will be carried out. Animal experiments (wound healing studies) will be conducted using diabetic mice showing delayed wound healing.
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